Immune regulation by peripheral suppressor T cells induced upon homotypic T cell/T cell interactions

Fibroblast and T cells conditioned media induce maturation dendritic cell and promote T helper immune response

Dendritic cells (DCs) induce pathogen-specific T cell responses. We comprehensively studied the effects of addition of maturation stimulus, fibroblasts (fibroblast conditioned medium), PHA activated T cells (T cell conditioned medium), and mixture of fibroblast & PHA activated T cells (FCM-TCCM) conditioned media on maturation of DCs. Monocytes were cultured with GM-CSF and IL-4 for five days. ...

Immune Amplification of Murine CD8+ Suppressor T Cells Induced via An Immune-Privileged Site: Quantifying Suppressor T Cells Functionally

BACKGROUND CD8(+) suppressor T cells exert antigen-specific suppression of the expression of hypersensitivity by activated T cells. Therefore, CD8(+) suppressor T cells serve a major regulatory role for the control of active immunity. Accordingly, the number and/or activity of CD8(+) suppressor T cells should be influenced by an immune response to the antigen. To test this hypothesis we used an...

Down-Regulation of T Cell Function by Heat Shock-Induced Excretory Factor of Leishmania Major

Background: Despite demonstration of molecular and biochemical changes induced by heat shock on Leishmania, the immunological importance of such changes has not been elucidated.  Objective: Studying the effect of two excretory factors prepared under heat shock and ambient temperature from Leishmania major on Balb/c splenocytes function.  Methods: The parasites were cultured at 25°C and then sub...

Regulation of immune responses by T cells.

n engl j med 354;11 www.nejm.org march 16, 2006 1166 From the Departments of Medicine (H.J., L.C.) and Pathology and Cell Biology (L.C.), Columbia University College of Physicians and Surgeons, New York. Address reprint requests to Dr. Jiang at the Department of Medicine (Rheumatology), Columbia University College of Physicians and Surgeons, 630 W. 168th St., New York, NY 10032, or at hj4@colum...

Immune Regulation by Self-Reactive T Cells